Plant-based research and pharmaceuticals have received notoriety in recent years due to challenges in both the agriculture and pharmaceutical industries. Global challenges facing the agriculture industry include hunger faced by a growing population, as well as drought and disease resistance. Pharmaceutical advances are now using plants to create vaccines for infections such as pandemic flu and Ebola. The facilities that are facing these challenges head on are "glass" laboratories, better known as greenhouses. Research Triangle Park has created an environment of world-leading innovation in the field of Agriculture Biotechnology and Pharmaceuticals, a uniquely skilled workforce, and collaboration with leading research institutions in the area has allowed growth and development of state-of-the-art facilities. This session will describe the challenges faced when designing R&D greenhouses while maintaining similar standards to laboratories such as biosafety level, cross-contamination prevention, high rate of air changes and environmental consistency.